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Specimen-specific™ Inhibitor Tolerant Master Mixes

A variety of different inhibitors inherent to clinical and environmental samples can negatively impact the sensitivity and accuracy of a molecular assay. Conventionally, to overcome this, specimens undergo extraction and processing prior to testing. However, extraction technologies are not 100% efficient which can impact the amount of target nucleic acid available for testing, and some inhibitors can co-elute following purification and induce false-negative assay results.
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Name Details Application Catalog Order a Sample Sizes Description Wet(Liquid) Air-Dryable Name Glycerol-Free Lyo-Ready Concentration High Concentration Detail Safety Data Sheet COA/Test Release User Guide Product Handling Guide Product Manual
Lyo-Ready AOF dUTP DNA qPCR Urine Urine, DNA qPCR MDX352 Order a Sample Available in 5 mL (1,000 Rxns) or 50 mL (10,000 Rxns) aliquots

An optimized qPCR master mix tolerant to inhibitors in urine. Perfect for multiplexing, high throughput assays where there is a greater risk of false positives from cross-over contamination.

 Liquid No Lyo-Ready Yes Yes 4x Yes View Details Safety Data Sheet COA/Test Release User Guide Product Handling Guide
Lyo-Ready AOF dUTP DNA qPCR Blood Blood, Plasma, Serum, DNA qPCR MDX322 Order a Sample Available in 5 mL (1,000 Rxns) or 50 mL (10,000 Rxns) aliquots

An optimized qPCR master mix tolerant to inhibitors in whole blood and plasma and compatible with all anticoagulants. Perfect for multiplexing, high throughput assays where there is a greater risk of false positives from cross-over contamination.

 Liquid No Lyo-Ready Yes Yes 4x Yes View Details Safety Data Sheet COA/Test Release User Guide Product Handling Guide
Lyo-Ready AOF dUTP DNA qPCR Saliva Saliva, Sputum, DNA qPCR MDX332 Order a Sample Available in 5 mL (1,000 Rxns) or 50 mL (10,000 Rxns) aliquots

An optimized qPCR master mix tolerant to inhibitors in saliva and sputum. Perfect for multiplexing, high throughput assays where there is a greater risk of false positives from cross-over contamination.

 Liquid No Lyo-Ready Yes Yes 4x Yes View Details Safety Data Sheet COA/Test Release User Guide Product Handling Guide
Lyo-Ready AOF dUTP RNA/DNA qPCR Blood Blood, Plasma, Serum, RNA RT-qPCR MDX323 Order a Sample Available in 5 mL (1,000 Rxns) or 50 mL (10,000 Rxns) aliquots

An optimized RT-qPCR master mix tolerant to inhibitors in whole blood and plasma and compatible with all anticoagulants. Perfect for multiplexing, high throughput assays where there is a greater risk of false positives from cross-over contamination.

 Liquid No Lyo-Ready Yes Yes 4x Yes View Details Safety Data Sheet COA/Test Release User Guide Product Handling Guide
Lyo-Ready AOF dUTP RNA/DNA qPCR Saliva Saliva, Sputum, RNA RT-qPCR MDX333 Order a Sample Available in 5 mL (1,000 Rxns) or 50 mL (10,000 Rxns) aliquots

An optimized RT-qPCR master mix tolerant to inhibitors in saliva and sputum. Perfect for multiplexing, high throughput assays where there is a greater risk of false positives from cross-over contamination.

 Liquid No Lyo-Ready Yes Yes 4x Yes View Details Safety Data Sheet COA/Test Release User Guide Product Handling Guide
Lyo-Ready AOF dUTP RNA/DNA qPCR Urine Urine, RNA RT-qPCR MDX353 Order a Sample Available in 5 mL (1,000 Rxns) or 50 mL (10,000 Rxns) aliquots

An optimized RT-qPCR master mix tolerant to inhibitors in urine. Perfect for multiplexing, high throughput assays where there is a greater risk of false positives from cross-over contamination.

 Liquid No Lyo-Ready Yes Yes 4x Yes View Details Safety Data Sheet COA/Test Release User Guide Product Handling Guide
Air-Dryable Direct DNA qPCR Blood, 4x Blood, Plasma, Serum, DNA qPCR MDX092 Order a Sample Available in 5 mL (1,000 Rxns) or 50 mL (10,000 Rxns) aliquots

Inhibitor tolerance to 20% whole blood, 20% plasma, compatible with all anticoagulants. Perfect for multiplexing and fast cycling conditions. Used in the detection of blood pathogens and liquid biopsy applications.

 Liquid Yes Air-Dryable Yes No 4x Yes View Details Safety Data Sheet COA/Test Release User Guide Product Handling Guide
Air-Dryable Direct DNA qPCR Plant, 4x Plant, DNA qPCR MDX116 Order a Sample Available in 5 mL (1,000 Rxns) or 50 mL (10,000 Rxns) aliquots

No need for extraction, compatible with 25% Plant lysate (SDS, NaOH). Perfect for multiplexing and fast cycling conditions for in-field qPCR testing. Used for genotyping and transgene or pathogenic detection.

 Liquid Yes Air-Dryable Yes No 4x Yes View Details Safety Data Sheet COA/Test Release User Guide Product Handling Guide
Air-Dryable Direct RNA/DNA qPCR Blood, 4x Blood, Plasma, Serum, RNA RT-qPCR MDX121 Order a Sample Available in 5 mL (1,000 Rxns) or 50 mL (10,000 Rxns) aliquots

Inhibitor tolerance to 10% whole blood, 10% plasma, compatible with all anticoagulants. Perfect for multiplexing and fast cycling conditions. Used in the detection of blood pathogens and liquid biopsy applications.

 Liquid Yes Air-Dryable Yes No 4x Yes View Details Safety Data Sheet COA/Test Release User Guide Product Handling Guide
Lyo-Ready Direct DNA qPCR Blood, 4x Blood, Plasma, Serum, DNA qPCR MDX122 Order a Sample Available in 5 mL (1,000 Rxns) or 50 mL (10,000 Rxns) aliquots

Inhibitor tolerance to 20% whole blood, 20% plasma, compatible with all anticoagulants. Perfect for multiplexing and fast cycling conditions. Used in the detection of blood pathogens and liquid biopsy applications.

 Liquid No Lyo-Ready Yes Yes 4x Yes View Details Safety Data Sheet COA/Test Release User Guide Product Handling Guide
Lyo-Ready Direct RNA/DNA qPCR Blood, 4x Blood, Plasma, Serum, RNA RT-qPCR MDX123 Order a Sample Available in 5 mL (1,000 Rxns) or 50 mL (10,000 Rxns) aliquots

Inhibitor tolerance to 10% whole blood, 10% plasma, compatible with all anticoagulants. Perfect for multiplexing and fast cycling conditions. Used in the detection of blood pathogens and liquid biopsy applications.

 Liquid No Lyo-Ready Yes Yes 4x Yes View Details Safety Data Sheet COA/Test Release User Guide Product Handling Guide
Lyo-Ready Direct DNA LAMP Blood, 4x Blood, Plasma, Serum, DNA LAMP MDX124 Order a Sample Available in 5 mL (1,000 Rxns) or 50 mL (10,000 Rxns) aliquots

Inhibitor tolerance to 20% whole blood, 20% plasma, compatible with all anticoagulants. Perfect for multiplexing and fast cycling conditions. Used in the detection of blood pathogens and liquid biopsy applications.

 Liquid No Lyo-Ready Yes Yes 4x Yes View Details Safety Data Sheet COA/Test Release User Guide Product Handling Guide
Lyo-Ready Direct RNA/DNA LAMP Blood, 4x Blood, Plasma, Serum, RNA RT-LAMP MDX125 Order a Sample Available in 5 mL (1,000 Rxns) or 50 mL (10,000 Rxns) aliquots

Inhibitor tolerance to 10% whole blood, 10% plasma, compatible with all anticoagulants. Perfect for multiplexing and fast cycling conditions. Used in the detection of blood pathogens and liquid biopsy applications.

 Liquid No Lyo-Ready Yes Yes 4x Yes View Details COA/Test Release User Guide Product Handling Guide
Lyo-Ready Genotyping Direct qPCR Blood, 4x Blood, Plasma, Serum, DNA SNP Genotyping MDX128 Order a Sample Available in 1,000 Unit or 10,000 Unit aliquots

Inhibitor tolerance to 10% whole blood, 20% plasma. Compatible with all dual-label probe chemistries for detection of genetic variants, such as single nucleotide and copy number variants, to give highly reproducible allelic discrimination.

 Liquid No Lyo-Ready Yes Yes 4x Yes View Details Safety Data Sheet COA/Test Release User Guide Product Handling Guide
Air-Dryable Direct DNA qPCR Saliva, 4x Saliva, Sputum, DNA qPCR MDX130 Order a Sample Available in 5 mL (1,000 Rxns) or 50 mL (10,000 Rxns) aliquots

Inhibitor tolerance to 60% crude saliva, sputum or mucin samples and 50% UTM. Perfect for multiplexing and fast cycling conditions. Used in the detection of a broad range of diseases, including cancer, respiratory viruses and bacterial infections.

 Liquid Yes Air-Dryable Yes No 4x Yes View Details Safety Data Sheet COA/Test Release Product Handling Guide
Air-Dryable Direct RNA/DNA qPCR Saliva, 4x Saliva, Sputum, RNA RT-qPCR MDX131 Order a Sample Available in 5 mL (1,000 Rxns) or 50 mL (10,000 Rxns) aliquots

Inhibitor tolerance to 60% crude saliva, sputum or mucin samples and 50% UTM. Perfect for multiplexing and fast cycling conditions. Used in the detection of a broad range of diseases, including cancer, respiratory viruses and bacterial infections.

 Liquid Yes Air-Dryable Yes No 4x Yes View Details Safety Data Sheet COA/Test Release User Guide Product Handling Guide
Lyo-Ready Direct DNA qPCR Saliva, 4x Saliva, Sputum, DNA qPCR MDX132 Order a Sample Available in 5 mL (1,000 Rxns) or 50 mL (10,000 Rxns) aliquots

Inhibitor tolerance to 60% crude saliva, sputum or mucin samples and 50% UTM. Perfect for multiplexing and fast cycling conditions. Used in the detection of a broad range of diseases, including cancer, respiratory viruses and bacterial infections.

 Liquid No Lyo-Ready Yes Yes 4x Yes View Details Safety Data Sheet COA/Test Release User Guide Product Handling Guide
Lyo-Ready Direct RNA/DNA qPCR Saliva, 4x Saliva, Sputum, RNA RT-qPCR MDX133 Order a Sample Available in 5 mL (1,000 Rxns) or 50 mL (10,000 Rxns) aliquots

Inhibitor tolerance to 60% crude saliva, sputum or mucin samples and 50% UTM. Perfect for multiplexing and fast cycling conditions. Used in the detection of a broad range of diseases, including cancer, respiratory viruses and bacterial infections.

 Liquid No Lyo-Ready Yes Yes 4x Yes View Details Safety Data Sheet COA/Test Release User Guide Product Handling Guide
Lyo-Ready Direct DNA LAMP Saliva, 4x Saliva, Sputum, DNA LAMP MDX134 Order a Sample Available in 5 mL (1,000 Rxns) or 50 mL (10,000 Rxns) aliquots

Inhibitor tolerance to 60% crude saliva, sputum or mucin samples and 50% UTM. Perfect for multiplexing and fast cycling conditions. Used in the detection of a broad range of diseases, including cancer, respiratory viruses and bacterial infections.

 Liquid No Lyo-Ready Yes Yes 4x Yes View Details Safety Data Sheet COA/Test Release User Guide Product Handling Guide
Lyo-Ready Direct RNA/DNA LAMP Saliva, 4x Saliva, Sputum, RNA RT-LAMP MDX135 Order a Sample Available in 5 mL (1,000 Rxns) or 50 mL (10,000 Rxns) aliquots

Inhibitor tolerance to 60% crude saliva, sputum or mucin samples and 50% UTM. Perfect for multiplexing and fast cycling conditions. Used in the detection of a broad range of diseases, including cancer, respiratory viruses and bacterial infections.

 Liquid No Lyo-Ready Yes Yes 4x Yes View Details Safety Data Sheet COA/Test Release User Guide Product Handling Guide
Air-Dryable Direct DNA qPCR Stool, 4x Stool, DNA qPCR MDX140 Order a Sample Available in 5 mL (1,000 Rxns) or 50 mL (10,000 Rxns) aliquots

Inhibitor tolerance to 20% stool, 2 mg/mL bile salt and 40% Cary Blair media. Perfect for multiplexing and fast cycling conditions. Used in the detection of IBD, cancer, fecal microbiota and bacterial and viruses.

 Liquid Yes Air-Dryable Yes No 4x Yes View Details Safety Data Sheet COA/Test Release Product Handling Guide
Air-Dryable Direct RNA/DNA qPCR Stool, 4x Stool, RNA RT-qPCR MDX141 Order a Sample Available in 5 mL (1,000 Rxns) or 50 mL (10,000 Rxns) aliquots

Inhibitor tolerance to 5% stool, 2 mg/mL bile salt and 40% Cary Blair media. Perfect for multiplexing and fast cycling conditions. Used in the detection of IBD, cancer, fecal microbiota and bacterial and viruses.

 Liquid Yes Air-Dryable Yes No 4x Yes View Details Safety Data Sheet COA/Test Release User Guide Product Handling Guide
Lyo-Ready Direct DNA qPCR Stool, 4x Stool, DNA qPCR MDX142 Order a Sample Available in 5 mL (1,000 Rxns) or 50 mL (10,000 Rxns) aliquots

Inhibitor tolerance to 20% stool, 2 mg/mL bile salt and 40% Cary Blair media. Perfect for multiplexing and fast cycling conditions. Used in the detection of IBD, cancer, fecal microbiota and bacterial and viruses.

 Liquid No Lyo-Ready Yes Yes 4x Yes View Details Safety Data Sheet COA/Test Release User Guide Product Handling Guide
Lyo-Ready Direct RNA/DNA qPCR Stool, 4x Stool, RNA RT-qPCR MDX143 Order a Sample Available in 5 mL (1,000 Rxns) or 50 mL (10,000 Rxns) aliquots

Inhibitor tolerance to 5% stool, 2 mg/mL bile salt and 40% Cary Blair media. Perfect for multiplexing and fast cycling conditions. Used in the detection of IBD, cancer, fecal microbiota and bacterial and viruses.

 Liquid No Lyo-Ready Yes Yes 4x Yes View Details Safety Data Sheet COA/Test Release User Guide Product Handling Guide
Lyo-Ready Direct DNA LAMP Stool, 4x Stool, DNA LAMP MDX144 Order a Sample Available in 5 mL (1,000 Rxns) or 50 mL (10,000 Rxns) aliquots

Inhibitor tolerance to 20% stool, 2 mg/mL bile salt and 40% Cary Blair media. Perfect for multiplexing and fast cycling conditions. Used in the detection of IBD, cancer, fecal microbiota and bacterial and viruses.

 Liquid No Lyo-Ready Yes Yes 4x Yes View Details Safety Data Sheet COA/Test Release User Guide Product Handling Guide
Lyo-Ready Direct RNA/DNA LAMP Stool, 4x Stool, RNA RT-LAMP MDX145 Order a Sample Available in 5 mL (1,000 Rxns) or 50 mL (10,000 Rxns) aliquots

Inhibitor tolerance to 5% stool, 2 mg/mL bile salt and 40% Cary Blair media. Perfect for multiplexing and fast cycling conditions. Used in the detection of IBD, cancer, fecal microbiota and bacterial and viruses.

 Liquid No Lyo-Ready Yes Yes 4x Yes View Details Safety Data Sheet COA/Test Release User Guide Product Handling Guide
Lyo-Ready Genotyping Direct qPCR Stool, 4x Stool, DNA SNP Genotyping MDX148 Order a Sample Available in 1,000 Unit or 10,000 Unit aliquots

Inhibitor tolerance to 20% stool. Compatible with all dual-label probe chemistries for detection of genetic variants, such as single nucleotide and copy number variants, to give highly reproducible allelic discrimination.

 Liquid No Lyo-Ready Yes Yes 4x Yes View Details COA/Test Release Product Handling Guide
Air-Dryable Direct DNA qPCR Urine, 4x Urine, DNA qPCR MDX150 Order a Sample Available in 5 mL (1,000 Rxns) or 50 mL (10,000 Rxns) aliquots

Inhibitor tolerance to 60% urine. Perfect for multiplexing and fast cycling conditions. Used in the detection of urinary track infections, STD, tropical diseases, cancer screening, bladder and prostate cancer.

 Liquid Yes Air-Dryable Yes No 4x Yes View Details Safety Data Sheet COA/Test Release Product Handling Guide
Air-Dryable Direct RNA/DNA qPCR Urine, 4x Urine, RNA RT-qPCR MDX151 Order a Sample Available in 5 mL (1,000 Rxns) or 50 mL (10,000 Rxns) aliquots

Inhibitor tolerance to 20% urine. Perfect for multiplexing and fast cycling conditions. Used in the detection of urinary track infections, STD, tropical diseases, cancer screening, bladder and prostate cancer.

 Liquid Yes Air-Dryable Yes No 4x Yes View Details Safety Data Sheet COA/Test Release User Guide Product Handling Guide
Lyo-Ready Direct DNA qPCR Urine, 4x Urine, DNA qPCR MDX152 Order a Sample Available in 5 mL (1,000 Rxns) or 50 mL (10,000 Rxns) aliquots

Inhibitor tolerance to 20% urine. Perfect for multiplexing and fast cycling conditions. Used in the detection of urinary track infections, STD, tropical diseases, cancer screening, bladder and prostate cancer.

 Liquid No Lyo-Ready Yes Yes 4x Yes View Details COA/Test Release User Guide Product Handling Guide
Lyo-Ready Direct RNA/DNA qPCR Urine, 4x Urine, RNA RT-qPCR MDX153 Order a Sample Available in 5 mL (1,000 Rxns) or 50 mL (10,000 Rxns) aliquots

Inhibitor tolerance to 20% urine. Perfect for multiplexing and fast cycling conditions. Used in the detection of urinary track infections, STD, tropical diseases, cancer screening, bladder and prostate cancer.

 Liquid No Lyo-Ready Yes Yes 4x Yes View Details COA/Test Release User Guide Product Handling Guide
Air-Dryable Direct DNA LAMP Blood, 4x Blood, Plasma, Serum, DNA LAMP MDX126 Order a Sample Available in 5 mL (1,000 Rxns) or 50 mL (10,000 Rxns) aliquots

Inhibitor tolerance to 10% whole blood, 10% plasma, compatible with all anticoagulants. Perfect for multiplexing and fast cycling conditions. Used in the detection of blood pathogens and liquid biopsy applications.

 Liquid Yes Air-Dryable Yes No 4x Yes View Details Safety Data Sheet COA/Test Release User Guide Product Handling Guide
Lyo-Ready Direct DNA LAMP Urine, 4x Urine, DNA LAMP MDX154 Order a Sample Available in 5 mL (1,000 Rxns) or 50 mL (10,000 Rxns) aliquots

Inhibitor tolerance to 20% urine. Perfect for multiplexing and fast cycling conditions. Used in the detection of urinary track infections, STD, tropical diseases, cancer screening, bladder and prostate cancer.

 Liquid No Lyo-Ready Yes Yes 4x Yes View Details COA/Test Release User Guide Product Handling Guide
Lyo-Ready Direct RNA/DNA LAMP Urine, 4x Urine, RNA RT-LAMP MDX155 Order a Sample Available in 5 mL (1,000 Rxns) or 50 mL (10,000 Rxns) aliquots

Inhibitor tolerance to 20% urine. Perfect for multiplexing and fast cycling conditions. Used in the detection of urinary track infections, STD, tropical diseases, cancer screening, bladder and prostate cancer.

 Liquid No Lyo-Ready Yes Yes 4x Yes View Details COA/Test Release User Guide Product Handling Guide
Lyo-Ready Genotyping Direct qPCR Urine, 4x Urine, DNA SNP Genotyping MDX158 Order a Sample Available in 1,000 Unit or 10,000 Unit aliquots

Inhibitor tolerance to 20% urine. Compatible with all dual-label probe chemistries for detection of genetic variants, such as single nucleotide and copy number variants, to give highly reproducible allelic discrimination.

 Liquid No Lyo-Ready Yes Yes 4x Yes View Details Safety Data Sheet COA/Test Release Product Handling Guide
Lyo-Ready Genotyping Direct qPCR FFPE, 4x FFPE, DNA SNP Genotyping MDX168 Order a Sample Available in 1,000 Unit or 10,000 Unit aliquots

Better extraction buffers and greater tolerance to crude FFPE samples. Compatible with all dual-label probe chemistries for detection of genetic variants, such as single nucleotide and copy number variants, to give highly reproducible allelic discrimination.

 Liquid No Lyo-Ready Yes Yes 4x Yes View Details COA/Test Release User Guide Product Handling Guide

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Sample Specific Inhibitor Tolerant qPCR and RT-qPCR Formulations

In developing universal inhibitor tolerant qPCR and RT-qPCR mixes, a compromise is required to accommodate all of the different types of inhibitors, this reduces sensitivity of the quantitative PCR. Meridian has therefore developed sample specific inhibitor tolerant qPCR and RT-qPCR formulations, designed to be used for direct amplification from crude lysates or inhibitor-rich samples either from blood, saliva, urine or stool. The ability of these mixes to tolerate the high level of PCR inhibitors present in these different sample types allows the development of simpler, faster multiplex qPCR assays that require minimal sample processing and fast turn-around times (TAT). This makes them ideal for liquid biopsy and point of care testing (POCT), where speed, sensitivity, and reproducibility are essential.

The mixes can be used as wet mixes or dried by lyophilization or air-drying, there are several advantages to this, including room temperature shipping and storage, extended shelf-life, and increased flexibility in the sample volume.

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